The home run by Hughes scored Austin Filiere and Michael Cruz to break a scoreless tie.
The TinCaps cut into the deficit in the seventh inning when Robbie Podorsky hit an RBI single, driving in Gabriel Arias.
Jeffrey Passantino (2-0) got the win in relief while Fort Wayne starter Tom Cosgrove (1-3) took the loss in the Midwest League game. Yapson Gomez pitched two scoreless innings for his first save of the season.
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