Trailing 6-1, the Mud Hens cut into the deficit in the third inning when Christin Stewart hit a two-run home run.
The Indians tacked on another run in the eighth when Christopher Bostick hit an RBI double, scoring Eric Wood.
Indianapolis starter Clay Holmes (1-0) picked up the win despite allowing three runs and five hits over five innings. Opposing starter Artie Lewicki (2-2) took the loss in the International League game after a rough outing in which he allowed six runs and 10 hits over 5 2/3 innings.
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